ABSTRACT
Objectives:To investigate the prevalence and related factors of cardiovascular diseases (CVD) and psychological problems in Chinese science and technology workers.Methods:The investigation was organized and conducted by the Innovative and Development Institute of China Association of Senior Scientists and Technologists and Capital Medical University Affiliated Beijing Anzhen Hospital, and included science and technology workers from research institutions and medical institutions in China by random sampling methods through face-to-face and online questionnaire investigation from July 1, 2019 to March 31, 2021. Information including age, sex, work stress status, CVD history, sleep, depression, and anxiety were included in the questionnaire.Results:This survey included 14 552 subjects. Among them, 25.5% were suffered from CVD, 48.6% were with insomnia, 28.8% experienced depression/anxiety (including only depression, only anxiety, depression combined with anxiety), and 15.6% had CVD in combined with depression/anxiety. Taking those without CVD and depression/anxiety as reference group, multiple logistic regression analyses showed that work stress increased the risk of depression/anxiety in subjects without CVD (manageable work stress, OR=2.253, 95 %CI 1.583-3.206, overwhelming work stress OR=7.899, 95 %CI 5.094-12.250), and drinking increased the risk of CVD ( OR=1.978, 95 %CI 1.382-2.833). Moreover, overwhelming work stress ( OR=4.012, 95 %CI 2.515-6.399) and smoking ( OR=2.342, 95 %CI 1.603-3.421) increased the risk of depression/anxiety in subjects with CVD (all P<0.001). Conclusion:The high morbidities of depression/anxiety, CVD, and CVD in combination with depression/anxiety urge us to take actions to protect the heart and mental health of scientific and technological workers.
ABSTRACT
Methamphetamine (MA) is a highly addictive psychostimulant that has effects on central nervous system.Chronic MA useis linked to serious neurotoxic effects and ultimately cognitive impairments, thus understanding the effect of chronic MA use on cognitive function can improve the treatment of MA abusers and reduce MA relapse. In the present study, we summarized the main results of animal experiments, neuropsychological studies and brain imaging studies on MA abuse and cognitive impairment, which may provide the basis for future research and clinical treatment.
ABSTRACT
An analytical method for the simultaneous determination of four quinolones in soil was developed. Soil samples were extracted by a mixture of 50% magnesium nitrate and 10% ammonia(96∶ 4, V/V)with an ultrasonic-assisted extraction, then purified and concentrated by HLB cartridge, and eluted with acetonitrile and 0.067 mol/L phosphoric acid(5∶ 1, V/V). Using acetonitrile and 0.067 mol/L phosphoric acid(pH=2.5) as the mobile phase, these analytes were quantificated by HPLC(fluorimetric detector) at excitation and emission wavelength of 280 nm and 450 nm respectively. The detective limits for four quinolones in soil were from 0.58 to 0.03 g/kg. The recoveries were 60.4% to 99.3% for soil samples. The method was successfully applied to determine the quinolones in soil samples from vegetable fields. Four quinolone compounds were detected to a different extent with total amounts of quinolones ranged from 27.84 to 129.26 μg/kg.
ABSTRACT
Objective To compare clinical effects of ropivacaine and hupivacaine administered in epidural space and study their pharmacokinetics and transfer across placenta. Methods Eighteen full-term nulliparous women aged 22-35yr, weighing 50-70 kg scheduled for cesarean section were randomized to one of two groups; group R received 0.75% ropivacame and group B received 0.5% hupivacaine for epidural block. Sensory and motor block, incidence of hypotension, blood gases of umbilical venous blood, Apgar score and NACS score of the neonates were investigated. Blood samples were taken from external jugular vein at 10, 15,30,60 and 120 min after epidural administration of local anesthetic and from umbilical vein for determination of plasma concentration of ropivacaine or bupivacaine by chromatography. Results The onset time and termination of sensory and motor block, the maximal height of block, incidence of hypotension, blood gases of umbilical venous blood, Apgar score and NACS score of the neonates were similar between the two groups. The plasma concentration of ropivacaine and bupivacaine peaked (613?90) ng.ml-1 and (51.3163.2) ng.ml-1 respectively, at 15-30 min after epidural administration. UV/ MV ratio was similar between the two groups (0.42 ? 0. 12 vs 0.48?0.15). Conclusion 0.75% ropivacaine and 0.5% bupivacaine administered in epidural space for cesarean section can produce adequate analgesia and equivalent clinical effects. Placental transfer of ropivacaine and bupivacaine are similar. The plasma concentration of ropivacaine and bupivacaine of maternal blood and umbilical venous blood are markedly lower than the concentration causing toxrcity, but safety margin of ropivacaine is wider than that of bupivacaine.